Metal Based Antimicrobials: Uses and Challenges

DA Salazar-Alemán, RJ Turner - Microbial Metabolism of Metals and …, 2022 - Springer
In this antimicrobial resistance era, where resistance to most antibiotics is commonplace,
metals and metalloid based antimicrobials (MBA) have emerged as an alternative to treat …

[HTML][HTML] The good, the bad, and the ugly of metals as antimicrobials

RJ Turner - Biometals, 2024 - Springer
We are now moving into the antimicrobial resistance (AMR) era where more antibiotic
resistant bacteria are now the majority, a problem brought on by both misuse and over use …

Antimicrobial activity of metals: mechanisms, molecular targets and applications

JA Lemire, JJ Harrison, RJ Turner - Nature Reviews Microbiology, 2013 - nature.com
Metals have been used as antimicrobial agents since antiquity, but throughout most of
history their modes of action have remained unclear. Recent studies indicate that different …

The potential of metals in combating bacterial pathogens

N Gugala, RJ Turner - Biomedical applications of metals, 2018 - Springer
The progression of antimicrobial resistance and the presence of microbial biofilms pose
serious threats, which have prompted the development of novel antimicrobials such as …

Metal-based antimicrobials

NK Monych, N Gugala, RJ Turner - 2019 - books.rsc.org
The introduction of antibiotics originated from the discovery of penicillin by Sir Alexander
Fleming in 1928, thus fueling a new medical era. 1 Antibiotics were once regarded as …

[HTML][HTML] Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action

JE Waters, L Stevens-Cullinane, L Siebenmann… - Current Opinion in …, 2023 - Elsevier
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning
threats to public health worldwide. With low economic incentives and a dwindling supply of …

Metal‐based antimicrobial strategies

RJ Turner - Microbial biotechnology, 2017 - Wiley Online Library
Metal based‐antimicrobials have potential for profiling sustainability solutions to infection
care and health; with biotechnological applications providing novel compounds. Yet they …

Elemental Analysis for the Characterization of Antimicrobial Effects

CHR Senges, JE Bandow - Antibiotics: Methods and Protocols, 2022 - Springer
To address the mounting resistance challenge, novel antibiotics and unprecedented
mechanisms of action are urgently needed. In this context, metals have attracted attention in …

Towards new antibiotics classes targeting bacterial metallophores

Z Ezzeddine, G Ghssein - Microbial Pathogenesis, 2023 - Elsevier
The increasing bacterial resistance caused by antibiotic overuse has promoted the search
for new antimicrobial strategies. Metals uptake via bacterial metallophores are studied to …

Rational approaches towards inorganic and organometallic antibacterials

J Hess - Biological chemistry, 2022 - degruyter.com
The occurrence of drug-resistant bacteria is drastically rising and new and effective antibiotic
classes are urgently needed. However, most of the compounds in development are minor …