Non-infectious autoimmune uveitis (NIU) in man is a heterogeneous group of diseases
characterized by inflammation of the uveal tract and adjacent ocular structures. 1 The …

Purpose: To investigate the role of damage-associated molecular patterns (DAMPs) in
recurrent experimental autoimmune uveitis (EAU). Methods: Recurrent EAU was induced in …

Uveitis is a diverse group of potentially sight-threatening intraocular inflammatory diseases
of infectious or autoimmune etiology and accounts for more than 10% of severe visual …

Autoimmune uveitis is an inflammatory disease affecting the inner eye of about 2‰ of the
western population. The disease is mediated by CD4+ Th1 cells (Calder et al., 1999), which …

Background It is not clear how invading autoreactive T cells initiate the pathogenic process
inside the diseased organ in T cell-mediated organ-specific autoimmune disease. In …

It is largely unknown how invading autoreactive T cells initiate the pathogenic process inside
the diseased organ in organ-specific autoimmune diseases. In experimental autoimmune …

Background Endogenous uveitis is a sight-threatening disease. In addition to
corticosteroids, immunosuppressive agents are commonly used to treat patients with severe …

Mouse models of experimental autoimmune uveitis (EAU) mimic unique features of human
uveitis, and serve as a template for preclinical study. The “classical” EAU model is induced …

Uveitis is a heterogeneous collection of diseases with polygenic and environmental
influences. This heterogeneity presents challenges in trial design and selection of end …

Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of
blindness worldwide. On the basis of aetiology, disease can be classified as infectious or …