Abstract Phosphatidylinositol 3‐kinase (PI3K), one member of lipid kinase family, has been
demonstrated to play a key role in regulating cell proliferation, adhesion, survival, and …

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …

The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

The dysregulation of the phosphatidylinositol-3-kinase (PI3K) pathway can lead to
uncontrolled cellular growth and tumorigenesis. Targeting PI3K and its downstream …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …

Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …

Cancer is a diverse class of diseases which differ widely in their cause and biology. The
aberrant behavior of cancer reflects up regulation of certain oncogenic signaling pathways …

Phosphatidylinositol 3-kinases (PI3Ks) are key molecules in the signal transduction
pathways initiated by the binding of extracellular signals to their cell surface receptors. The …

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway, being important in
apoptosis hence cancer such as breast cancer and non-small-cell lung cancer. It signaling …