Curcumin raises lipid content by Wnt pathway in hepatic stellate cell
F Zhang, C Lu, W Xu, J Shao, L Wu, Y Lu… - Journal of Surgical …, 2016 - Elsevier
Background Activation of hepatic stellate cells (HSCs) is a pivotal event in liver fibrosis,
which is characterized by dramatic disappearance of lipid droplets. However, the underlying …
which is characterized by dramatic disappearance of lipid droplets. However, the underlying …
Curcumin suppresses expression of low‐density lipoprotein (LDL) receptor, leading to the inhibition of LDL‐induced activation of hepatic stellate cells
Q Kang, A Chen - British journal of pharmacology, 2009 - Wiley Online Library
Background and purpose: Obesity is often accompanied by hypercholesterolemia
characterized by elevated levels of plasma low‐density lipoprotein (LDL) and associated …
characterized by elevated levels of plasma low‐density lipoprotein (LDL) and associated …
[HTML][HTML] Wnt5a participates in hepatic stellate cell activation observed by gene expression profile and functional assays
WJ Xiong, LJ Hu, YC Jian, LJ Wang… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …
Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
F Jiang, CJ Parsons, B Stefanovic - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …
Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
X Han, S Xu, J Lin - Current Medical Science, 2019 - Springer
The activation of hepatic stellate cells (HSCs) is a major event during hepatic fibrogenesis.
Restoration of intracellular lipid droplet (LD) formation turns the activated HSC back to a …
Restoration of intracellular lipid droplet (LD) formation turns the activated HSC back to a …
Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
C Kordes, I Sawitza, D Häussinger - Biochemical and biophysical research …, 2008 - Elsevier
It is well known that hepatic stellate cells (HSC) develop into cells, which are thought to
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …
contribute to liver fibrogenesis. Recent data suggest that HSC are progenitor cells with the …
[HTML][HTML] Inhibition of canonical WNT signaling pathway by β-catenin/CBP inhibitor ICG-001 ameliorates liver fibrosis in vivo through suppression of stromal CXCL12
Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …
morphological transformation into proliferative, contractile and ECM-producing …
Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase
N Lian, H Jin, F Zhang, L Wu, J Shao, Y Lu… - Iubmb Life, 2016 - Wiley Online Library
Activation of hepatic stellate cells (HSCs) is characterized by expression of extracellular
matrix and loss of adipogenic phenotype during liver fibrogenesis. Emerging evidence …
matrix and loss of adipogenic phenotype during liver fibrogenesis. Emerging evidence …
Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis
JH Cheng, H She, YP Han, J Wang… - American Journal …, 2008 - journals.physiology.org
Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …
diminished adipogenic transcription. This study investigated whether Wnt signaling …
Wnt5a Promotes Cytokines Production and Cell Proliferation in Human Hepatic Stellate Cells Independent of Canonical Wnt Pathway.
S Dong, C Wu, J Hu, Q Wang, S Chen, W Zhirong… - Clinical …, 2015 - europepmc.org
Background Wnt5a is involved in the activation of human hepatic stellate cells (HSC) and
related with the occurrence of liver fibrosis. As the function and mechanism that Wnt5a …
related with the occurrence of liver fibrosis. As the function and mechanism that Wnt5a …