Purpose: Alteration of the BRAF/MEK/MAPK pathway is the hallmark of pediatric low-grade
gliomas (PLGGs), and mTOR activation has been documented in the majority of these …

Simple Summary This review is divided into two parts. The first analyzes the mechanisms of
two important cellular pathways that are involved in tumoral proliferation, differentiation …

PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor
outcomes with current chemoradiotherapy strategies. Our aim was to study the role of …

Activating mutation of BRAF is a common finding in pediatric gliomas. As many as 14% of
high grade and up to 66% of certain subtypes of low grade pediatric glioma have the BRAF …

Pediatric low-grade gliomas (PLGGs), the most common group of brain tumors in children,
are molecularly and clinically heterogeneous with a propensity for indolent progression …

The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most
commonly mutated pathways in human cancers. In particular, BRAF alterations result in …

Purpose: Malignant astrocytomas (MA) are aggressive central nervous system tumors with
poor prognosis. Activating mutation of BRAF (BRAFV600E) has been reported in a subset of …

Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain
elusive. The BRAF mutation V600E is critical to the pathogenesis of 10–20% of pediatric …

BRAFV600E represents the most common BRAF mutation in all human cancers. Among
central nervous system (CNS) tumors, BRAFV600E is mostly found in pediatric low-grade …

Abstract BRAF V600E is a common finding in glioma (about 10–60% depending on
histopathologic subclassification). BRAF V600E monotherapy shows modest preclinical …