Class I major histocompatibility complex (MHC) molecules are ternary complexes of the
soluble serum protein beta 2-microglobulin, MHC heavy chain, and bound peptide. The first …

Dynamic interactions between major histocompatibility complex (MHC) class I heavy chains
and β2-microglobulin (β2m) play a critical role in their stability on the cell surface, and their …

Heterodimeric class I major histocompatibility complex molecules, which consist of a 45-kDa
heavy-chain and a 12-kDa beta 2-microglobulin (beta 2m) light chain, bind endogenously …

We have identified two forms of a major histocompatibility complex (MHC) class I molecule,
H-2Kb, distinguishable by specific antibodies through a study of a genetically engineered …

The three‐dimensional structures of three human and two murine class I molecules, in
complex with single peptides and with mixtures of endogenous peptides, have now been …

The major histocompatibility complex-encoded class I molecule, a noncovalent dimer of a
polymorphic 45-kDa heavy chain and a nonpolymorphic 12-kDa beta 2-microglobulin (beta …

Class I major histocompatibility complexes (MHC) are heterotrimeric structures comprising
heavy chains (HC), β 2-microglobulin (β 2-m), and short antigenic peptides of 8–10 amino …

The function of major histocompatibility complex (MHC) class I molecules is to sample
peptides derived from intracellular proteins and to present these peptides to CD8+ cytotoxic …

The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a
major histocompatibility complex (MHC) heavy chain, β2‐microglobulin (β2M), and peptide …

X-ray crystallographic analysis of human major histocompatibility complex (MHC) class I
glycoproteins has shown that there is extremely intimate contact between the bound peptide …