POS0545 CONSIDERING BELIMUMAB DURING PREGNANCY: A MORE VIABLE OPTION OVER TIME

PV Casasempere, R Caño, S Gómez, SC Aznar… - 2024 - ard.bmj.com
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects
women of childbearing age, multiplying pregnancy complications 2-4 times. According to …

OP0041 Pregnancy outcomes for systemic lupus erythematosus (SLE) subjects with conception during belimumab intravenous (IV) and subcutaneous (SC) placebo …

M Powell, D Hill, A Eudy, H Landy… - Annals of the Rheumatic …, 2014 - ard.bmj.com
Background SLE is an autoimmune disease typically affecting women of childbearing age
that can be associated with significant maternal and fetal morbidity. Belimumab is a biologic …

Favorable pregnancy outcomes in two patients with systemic lupus erythematosus treated with belimumab

SR Wei, ZZ Zhu, J Xu, HY Mo - International Journal of …, 2023 - Wiley Online Library
Background Systemic lupus erythematosus (SLE) is associated with poor pregnancy
outcomes and complications. Belimumab can significantly improve disease activity in …

POS0702 Pregnancy in SLE patients treated with belimumab: experience from 3 italian centers

F Crisafulli, MC Gerardi, L Moschetti, M Fredi, C Nalli… - 2021 - ard.bmj.com
Background: Belimumab (BEL) is a monoclonal antibody approved for SLE treatment but
few data are available about its use before or during pregnancy. Objectives: Our study aims …

Transplacental passage of belimumab during pregnancy and follow-up of a child exposed in utero

H Bitter, DJ Warren, N Bolstad, ALI Noraas… - Annals of the …, 2023 - ard.bmj.com
A recent report from the Belimumab Pregnancy Registry (NCT01532310) analysed available
data on the consequences of belimumab (BEL) use in pregnant women with systemic lupus …

A case report of two systemic lupus erythematosus pregnancies with early placental exposure to belimumab: case report with review

T Nakai, Y Ikeda, K Yamaguchi, T Asano… - Modern …, 2023 - academic.oup.com
Since its approval for the management of systemic lupus erythematosus (SLE), belimumab
has been widely used. However, its pregnancy safety profile has been underinvestigated …

Use of belimumab throughout pregnancy to treat active systemic lupus erythematosus—a case report

A Danve, L Perry, A Deodhar - Seminars in arthritis and rheumatism, 2014 - Elsevier
Background Pregnancy can lead to flares in systemic lupus erythematosus (SLE), and the
presence of SLE in pregnancy could lead to a poor outcome for the mother and the fetus …

Belimumab use during pregnancy: a summary of birth defects and pregnancy loss from belimumab clinical trials, a pregnancy registry and postmarketing reports

M Petri, H Landy, MEB Clowse, K Gemzoe… - Annals of the …, 2023 - ard.bmj.com
Objective Describe available data on birth defects and pregnancy loss in women with
systemic lupus erythematosus (SLE) exposed to belimumab. Methods Data collected from …

Dilemma of belimumab therapy (dis) continuation during pregnancy: Results of a retrospective study in eudravigilance

N Ghalandari, HJMJ Crijns, RJEM Dolhain… - Lupus, 2023 - journals.sagepub.com
Introduction The first biologic authorized for systemic lupus erythematosus (SLE) up to this
date, belimumab, is currently not recommended for use during pregnancy due to lack of …

Different pregnancy outcomes in patients with systemic lupus erythematosus treated with belimumab

Y Lai, B Li, J Huang, J Du, M Yue, X Shen, X Liu… - Lupus, 2023 - journals.sagepub.com
Objectives Systemic lupus erythematosus (SLE) predominantly occurs in women of child-
bearing age. Selecting drugs for pregnant SLE patients has always been a difficult choice …