Heparan sulfate proteoglycans are a remarkably diverse family of glycosaminoglycan-
bearing protein cores that include the syndecans, the glypicans, perlecan, agrin, and …

Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …

Proteoglycans are abundant components of the cell surface and extracellular matrix that
mediate critical interactions between cells and their environment. They play a variety of …

Although heparan sulfate has been known since its discovery 50 years ago by Jorpes and
Gardell (1948), only recently has its importance to the cellular economy become apparent …

Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor‐receptor
interactions, accelerates the formation of specific proteinase‐proteinase inhibitor complexes …

Proteoglycans were first discovered in basement membranes by the presence of their sulfate
esters and their ability to be detected with cationic dyes (1, 2). The presence of heparan …

This book provides a comprehensive, up-to-date review of the structure, biology, and
molecular interactions of proteoglycans, consolidating into a single source research using …

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular
matrix in all the animal species. This review will focus on the structural characteristics of the …

Heparan sulfate (HS) and chondroitin sulfate (CS) are complex polysaccharides that
regulate important biological pathways in virtually all metazoan organisms. The …

Large numbers of proteins in animal tissues occur immobilized in the extracellular space, at
cell surfaces or in the extracellular matrix. Some are anchored through interactions with …