Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience
Mental health disorders often arise as a combination of environmental and genetic factors.
The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key …
The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
FKBP5 polymorphisms induce differential glucocorticoid responsiveness in primary CNS cells – First insights from novel humanized mice
V Nold, N Richter, B Hengerer… - European Journal of …, 2021 - Wiley Online Library
The brain is a central hub for integration of internal and external conditions and, thus, a
regulator of the stress response. Glucocorticoids are the essential communicators of this …
regulator of the stress response. Glucocorticoids are the essential communicators of this …
Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Identification and characterisation of novel targets for treatment is a priority in the field of
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …
Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain
SH Scharf, C Liebl, EB Binder, MV Schmidt, MB Müller - PloS one, 2011 - journals.plos.org
Background Chronic stress has been found to be a major risk factor for various human
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
[HTML][HTML] Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans
L Herrmann, T Ebert, H Rosen, B Novak… - Neurobiology of …, 2021 - Elsevier
As the cerebellar molecular stress response is understudied, we assessed protein
expression levels of hypothalamic-pituitary-adrenal (HPA) axis regulators and …
expression levels of hypothalamic-pituitary-adrenal (HPA) axis regulators and …
Depletion of FKBP51 in female mice shapes HPA axis activity
L Hoeijmakers, D Harbich, B Schmid, PJ Lucassen… - PLoS …, 2014 - journals.plos.org
Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a
major disease burden worldwide and have a higher incidence in women than in men …
major disease burden worldwide and have a higher incidence in women than in men …
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene
combine with traumatic events to increase risk for post-traumatic stress and major …
combine with traumatic events to increase risk for post-traumatic stress and major …
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance
JC O'Leary III, B Zhang, J Koren III… - CNS & Neurological …, 2013 - benthamdirect.com
Research on the FKBP5 gene and FKBP51 protein has more than doubled since the
discovery that polymorphisms in this gene could alter treatment outcomes and depressive …
discovery that polymorphisms in this gene could alter treatment outcomes and depressive …