The FKBP5 gene codifies a co-chaperone protein associated with the modulation of
glucocorticoid receptor interaction involved in the adaptive stress response. The FKBP5 …

Abstract FK506 binding protein 51 (FKBP5) is a co‐chaperone of heat shock protein 90 and
significantly influences glucocorticoid receptor sensitivity. Single nucleotide polymorphisms …

Glucocorticoid (GC)-mediated negative feedback of the hypothalamic-pituitary-adrenal
(HPA) axis, the body's physiological stress response system, is tightly regulated and …

Although a large number of recent studies indicate strong association of FKBP5 (aka
FKBP51) functions with various stress-related psychiatric disorders, the overall mechanisms …

FKBP51 is a key stress-responsive regulator of the hypothalamic–pituitary–adrenal axis. To
elucidate the contribution of rs1360780 FKBP5 C/T alleles to aging and longevity, we …

The cumulative load of genetic predisposition, early life adversity (ELA) and lifestyle shapes
the prevalence of psychiatric disorders. Single nucleotide polymorphisms (SNPs) in the …

The FK506 binding protein 51 (FKBP5), an intrinsic regulator of the glucocorticoid receptor,
has been associated with pathological behaviors particularly in the context of childhood …

Epidemiological studies indicate a combined contribution of genetic and environmental
factors, mainly exposure to adverse life events, in the risk for psychiatric disease …

Background Inflammation is a potential risk factor of mental disturbance. FKBP5 that
encodes FK506-binding protein 51 (FKBP51), a negative cochaperone of glucocorticoid …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …