Advances in C. áelegans behavior research with microfluidic devices and its future prospects in the evaluation of exogenous pollutants

X Zhang, J Sun, X Yuan, X Lu, X Sun - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
The nematode Caenorhabditis elegans (C. áelegans) is characterized by small size, a
transparent body, and a simple structure. However, traditional techniques (eg, sorting and …

Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays

F Kamili, H Lu - Annual Review of Analytical Chemistry, 2018 - annualreviews.org
Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans
research community in particular has developed a variety of microfluidic platforms to …

Analysis of Caenorhabditis elegans in microfluidic devices

H Wen, JH Qin - Science China Chemistry, 2012 - Springer
Caenorhabditis elegans (C. elegans) is widely adopted as a model organism for a variety of
biological studies including development, genetics and neurobiology. Micro-scale …

A microfluidic device for efficient chemical testing using Caenorhabditis elegans

P Song, W Zhang, A Sobolevski, K Bernard… - Biomedical …, 2015 - Springer
The nematode worm Caenorhabditis elegans has been employed as a popular model
organism in many fields of biological research. In this paper, we present a microfluidic …

Microfluidic chamber arrays for whole-organism behavior-based chemical screening

K Chung, M Zhan, J Srinivasan, PW Sternberg… - Lab on a Chip, 2011 - pubs.rsc.org
The nematode Caenorhabditis elegans is an important model organism in genetic research
and drug screening because of its relative simplicity, ease of maintenance, amenability to …

Microfluidic Devices in Advanced Caenorhabditis elegans Research

M Muthaiyan Shanmugam, T Subhra Santra - Molecules, 2016 - mdpi.com
The study of model organisms is very important in view of their potential for application to
human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis …

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Microfluidics for the analysis of behavior, nerve regeneration, and neural cell biology in C. elegans

A Ben-Yakar, N Chronis, H Lu - Current opinion in neurobiology, 2009 - Elsevier
The nematode Caenorhabditis elegans is a widely adopted model organism for studying
various neurobiological processes at the molecular and cellular level in vivo. With a small …

Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics

R Lycke, A Parashar, S Pandey - Biomicrofluidics, 2013 - pubs.aip.org
The discovery of new drugs is often propelled by the increasing resistance of parasites to
existing drugs and the availability of better technology platforms. The area of microfluidics …

Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans

D Midkiff, A San-Miguel - Molecules, 2019 - mdpi.com
The nematode Caenorhabditis elegans is a powerful model organism that has been widely
used to study molecular biology, cell development, neurobiology, and aging. Despite their …