Innate recognition of DNA within intracellular compartments or the cytoplasm leads to
activation of the immune system, which can result in defense against DNA virus infections or …

Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1β (IL-
1β) as an antiviral host response, and deregulation of the pathways involved can promote …

Rad50 and CARD9, missing links in cytosolic DNA–stimulated inflammation | Nature
Immunology Skip to main content Thank you for visiting nature.com. You are using a browser …

Mammalian innate immunity possesses a distinct system to recognize aberrant DNA inside
the cell. One class of DNA sensors is the Toll-like receptor 9, which is expressed in the …

Microbial sensing mediated by pattern recognition receptors (PRRs) is the first key step to
trigger innate immune responses, represented by the induction of type I interferons (IFNs) …

In mammals, cytosolic detection of nucleic acids is critical in initiating innate antiviral
responses against invading pathogens (like bacteria, viruses, fungi and parasites). These …

Innate immune DNA sensing underpins many physiological and pathological responses to
DNA, including anti-viral immunity to DNA viruses. Although it has been appreciated for …

DNA is immunogenic and many cells express cytosolic DNA sensors that activate the
stimulator of interferon genes (STING) adaptor to trigger interferon type I (IFN‐β) release, a …

In two recent reports in Science, James Chen and colleagues provide compelling evidence
that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic …

To mount an efficient interferon response to virus infection, intracellular pattern recognition
receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The …