BNT162b2 vaccination elicits strong serological immune responses against SARS-CoV-2 including variants of concern in elderly convalescents

B Jahrsdörfer, D Fabricius, J Scholz, C Ludwig… - Frontiers in …, 2021 - frontiersin.org
Elderly residents of long-term care facilities (LTCFs) have long been underrepresented in
studies on vaccine efficacy, particularly in light of currently emerging variants of concern …

Immune responses against SARS-CoV-2 WT and delta variant in elderly BNT162b2 vaccinees

M Jäger, ST Sonnleitner, S Dichtl, E Lafon… - Frontiers in …, 2022 - frontiersin.org
Background Residents of nursing homes are one of the most vulnerable groups during the
severe acute syndrome coronavirus 2 (SARS-CoV-2) pandemic. The aim of this study was to …

Characterization of the humoral immune response to BNT162b2 in elderly residents of long-term care facilities five to seven months after vaccination

M Delbrück, S Hoehl, T Toptan, B Schenk, K Grikscheit… - medrxiv, 2021 - medrxiv.org
The elderly residing in long-term care facilities (LTCFs) are a group at high risk for COVID-
19. Hence, monitoring of the vaccine-based immunity has a pivotal role in identifying …

Reduced humoral response 3 months following BNT162b2 vaccination in SARS-CoV-2 uninfected residents of long-term care facilities

M Trigueros, E Pradenas, D Palacín… - Age and …, 2022 - academic.oup.com
Background SARS-CoV-2 vaccination is the most effective strategy to protect older residents
of long-term care facilities (LTCF) against severe COVID-19, but primary vaccine responses …

Humoral and Cellular Immune Response Elicited by the BNT162b2 COVID-19 Vaccine Booster in Elderly

D Dalla Gasperina, G Veronesi, CM Castelletti… - International Journal of …, 2023 - mdpi.com
Although the safety and efficacy of COVID-19 vaccines in older people are critical to their
success, little is known about their immunogenicity among elderly residents of long-term …

BNT162b2 booster vaccination elicits cross-reactive immunity against SARS-CoV-2 variants B. 1.1. 529 and B. 1.617. 2 in convalescents of all ages

B Jahrsdörfer, M Proffen, J Scholz, J Hägele… - Frontiers in …, 2022 - frontiersin.org
In this prospective observational cohort study we analyzed cellular and serological immune
response parameters against SARS-CoV-2 and current variants of concern (VOC) in 147 …

Humoral and cellular responses to COVID-19 vaccination indicate the need for post-vaccination testing in frail population

W Witkowski, S Gerlo, E De Smet, M Wejda, D Acar… - Vaccines, 2022 - mdpi.com
Despite the high efficacy of the BNT162b2 vaccine in the general population, data on its
immunogenicity among frail elderly individuals are limited. Recently, levels of anti-SARS …

Effect of vaccine booster, vaccine type, and hybrid immunity on humoral and cellular immunity against SARS-CoV-2 ancestral strain and Omicron variant sublineages …

CHY Fong, X Zhang, LL Chen, RWS Poon… - …, 2023 - thelancet.com
Background Vaccination reduces COVID-19-related hospitalization among older adults.
However, how SARS-CoV-2 infection and vaccine regimens affect vaccine-elicited immunity …

[HTML][HTML] Durable immune responses after BNT162b2 vaccination in home-dwelling old adults

L Hansen, KA Brokstad, A Bansal, F Zhou, G Bredholt… - Vaccine: X, 2023 - Elsevier
Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We
comprehensively analyzed the durability of humoral and cellular immune responses after …

Hybrid immunity in older adults is associated with reduced SARS-CoV-2 infections following BNT162b2 COVID-19 immunisation

SJC Pallett, J Heskin, F Keating, A Mazzella… - Communications …, 2023 - nature.com
Background Older adults, particularly in long-term care facilities (LTCF), remain at
considerable risk from SARS-CoV-2. Data on the protective effect and mechanisms of hybrid …