Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats

PJW Smith, O Ornatsky, DJ Stewart, P Picard… - Circulation, 2000 - Am Heart Assoc
Background—Estrogen may increase the long-term survival of women who have suffered
from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen …

17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction

M van Eickels, RD Patten, MJ Aronovitz… - Journal of the American …, 2003 - jacc.org
Objectives: This study was designed to examine the effects of estrogen replacement on
infarct size, ventricular remodeling, and mortality after myocardial infarction (MI) in mice …

Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling

S Hügel, M Reincke, H Strömer, J Winning… - Journal of the American …, 1999 - jacc.org
OBJECTIVES The purpose of this study was to examine whether endogenous estrogen
deficiency induced by ovariectomy affects chronic left ventricular dysfunction post …

Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor‐specific mechanisms

FA Babiker, DJ Lips, E Delvaux, P Zandberg… - Acta …, 2007 - Wiley Online Library
Aim: Observational and clinical studies suggest different responses upon sex hormone
replacement therapy in ischaemic heart disease. Few studies, however, have examined the …

Estrogen replacement and cardiomyocyte protection

RD Patten, RH Karas - Trends in cardiovascular medicine, 2006 - Elsevier
The effects of estrogen on vascular function have been studied extensively; however, much
less is known regarding the effect of estrogen on myocardial function and cardiomyocyte …

Dose‐dependent cardiac effect of oestrogen replacement in mice post‐myocardial infarction

E Zhan, T Keimig, J Xu, E Peterson… - Experimental …, 2008 - Wiley Online Library
Hormonal replacement therapy (HRT) has recently been shown to increase the risk of
cardiovascular events in women. However, it is not clear whether the adverse effect of HRT …

Effect of 6-wk estrogen withdrawal or replacement on myocardial ischemic tolerance in rats

PH McNulty, D Jagasia, JM Whiting… - American Journal of …, 2000 - journals.physiology.org
Menopausal status is a risk factor for coronary artery disease death, but the mechanism
underlying this association is uncertain. To test whether estrogen ameliorates the effects of …

β-Estradiol, but not α-estradiol, reduces myocardial necrosis in rabbits after ischemia and reperfusion

SL Hale, Y Birnbaum, RA Kloner - American heart journal, 1996 - Elsevier
Recent studies in several animal models have suggested that estrogen, given for the short
term, may protect ischemic myocardium. Our objective was to test the effect of exogenous …

High-dose 17β–estradiol treatment prevents development of heart failure post–myocardial infarction in the rat

S Beer, M Reincke, M Kral, F Callies, H Strömer… - Basic research in …, 2007 - Springer
Objectives Prognosis of heart failure remains poor despite therapeutic advances, such as
angiotensin converting enzyme inhibition or β-receptor blockade. Thus, more effective forms …

Unravelling the cardioprotective mechanism of action of estrogens

JA Moolman - Cardiovascular research, 2006 - academic.oup.com
Cardiovascular diseases are the major cause of morbidity and mortality in the developed
world, and are increasing in significance in the developing world. Elucidation of the …