Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that
leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and …

Clostridium difficile is the leading cause of hospital-acquired diarrhea in Europe and North
America and is a serious reemerging pathogen. Recent outbreaks have led to increasing …

Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea, and
is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of …

■ ABSTRACT Clostridium difficile-associated disease (CDAD) can range from
uncomplicated diarrhea to sepsis and even death. CDAD rates and severity are increasing …

Clostridium difficile is one of the most important causes of healthcare acquired diarrhea. The
disease spectrum caused by C. difficile infection ranges from mild, self-limited, illness to a …

Clostridium difficile was identified as the leading cause of antibiotic-associated diarrhea and
colitis in 1978, but since 2001 C difficile infections (CDIs) have evolved from sporadic …

Clostridium difficile is the most frequent cause of nosocomial antibiotic-associated diarrhea.
The incidence of C. difficile infection (CDI) has been rising worldwide with subsequent …

Clostridium difficile is a spore-forming gram-positive bacillus, and the leading cause of
antibiotic-associated nosocomial diarrhea and colitis in the industrialized world. With the …

After being considered a manageable pathogen for decades, C. difficile recently caused
large outbreaks of severe disease. Refocused research is determining patients who are at …

Clostridium difficile is now considered to be one of the most important causes of health care-
associated infections. C. difficile infections are also emerging in the community and in …