Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study
Wilms tumors (WT) have provided broad insights into the interface between development
and tumorigenesis. Further understanding is confounded by their genetic, histologic, and …
and tumorigenesis. Further understanding is confounded by their genetic, histologic, and …
Wilms tumour
F Spreafico, CV Fernandez, J Brok, K Nakata… - Nature Reviews …, 2021 - nature.com
Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
[HTML][HTML] Stratification of Wilms tumor by genetic and epigenetic analysis
RH Scott, A Murray, L Baskcomb, C Turnbull… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are
implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we …
implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we …
Pathology, genetics and cytogenetics of Wilms' tumour
RM Zin, A Murch, A Charles - Pathology-Journal of the RCPA, 2011 - journals.lww.com
Wilms' tumour (WT) is an embryonal cancer of childhood and is thought to be derived from
embryonic kidney precursor cells. The Knudson two hit model was initially thought to occur …
embryonic kidney precursor cells. The Knudson two hit model was initially thought to occur …
Biomarkers to detect Wilms tumors in pediatric patients: where are we now?
J Charlton, V Pavasovic, K Pritchard-Jones - Future Oncology, 2015 - Taylor & Francis
Wilms tumor (WT) is the most common pediatric renal tumor. Survival rates are high, whether
treated according to the European protocols (SIOP-RTSG) that use prenephrectomy …
treated according to the European protocols (SIOP-RTSG) that use prenephrectomy …
The molecular biology of Wilms' tumour
Wilms' tumour (WT; nephroblastoma), a kidney neoplasm, is one of the most frequently
occurring solid tumours of childhood. It arises from the developing kidney by genetic and …
occurring solid tumours of childhood. It arises from the developing kidney by genetic and …
Wilms tumor: an update
T Al-Hussain, A Ali, M Akhtar - Advances in anatomic pathology, 2014 - journals.lww.com
Wilms tumor (WT) is the most common neoplasm of the kidney in children. It is an
embryologic tumor that histologically mimics renal embryogenesis and is composed of a …
embryologic tumor that histologically mimics renal embryogenesis and is composed of a …
Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes
R Fukuzawa, MR Anaka, RW Heathcott… - The Journal of …, 2008 - Wiley Online Library
Current models of Wilms tumour development propose that histological features of the
tumours are programmed by the underlying molecular aberrations. For example, tumours …
tumours are programmed by the underlying molecular aberrations. For example, tumours …
Wilms' tumour: connecting tumorigenesis and organ development in the kidney
MN Rivera, DA Haber - Nature Reviews Cancer, 2005 - nature.com
Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to
early kidney development and is often associated with persistent embryonic renal tissue and …
early kidney development and is often associated with persistent embryonic renal tissue and …