With the increasing prevalence of obesity, research has focused on the molecular
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …

Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the
development of type 2 diabetes mellitus. Insulin resistance is associated with the …

Imbalance between nutritional intake and energy expenditure has been described to
culminate in obesity, which predisposes to insulin resistance and type 2 diabetes mellitus. In …

Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues
such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

ABSTRACT BERGGREN, JR, MW HULVER, GL DOHM, and JA HOUMARD. Weight Loss
and Exercise: Implications for Muscle Lipid Metabolism and Insulin Action. Med. Sci. Sports …

Obesity predisposes individuals to the development of insulin resistance, which is a risk
factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin …

There is interest in how altered lipid metabolism could contribute to muscle insulin
resistance. Many animal and human states of insulin resistance have increased muscle …

Skeletal muscle from sedentary obese patients is characterized by depressed electron
transport activity, reduced expression of genes required for oxidative metabolism, altered …

An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …