Structural and evolutionary analyses reveal determinants of DNA binding specificities of nucleoid-associated proteins HU and IHF

D Dey, V Nagaraja, S Ramakumar - Molecular phylogenetics and evolution, 2017 - Elsevier
Nucleoid-associated proteins (NAPs) are chromosome-organizing factors, which affect the
transcriptional landscape of a bacterial cell. HU is an NAP, which binds to DNA with a broad …

Genomic analysis of DNA binding and gene regulation by homologous nucleoid-associated proteins IHF and HU in Escherichia coli K12

AI Prieto, C Kahramanoglou, RM Ali… - Nucleic acids …, 2012 - academic.oup.com
IHF and HU are two heterodimeric nucleoid-associated proteins (NAP) that belong to the
same protein family but interact differently with the DNA. IHF is a sequence-specific DNA …

Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment

D Kamashev, Y Agapova, S Rastorguev, AA Talyzina… - PloS one, 2017 - journals.plos.org
Background The structure and function of bacterial nucleoid are controlled by histone-like
proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some …

[HTML][HTML] Nucleoid-associated protein HU: A lilliputian in gene regulation of bacterial virulence

P Stojkova, P Spidlova, J Stulik - Frontiers in cellular and infection …, 2019 - frontiersin.org
Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial
cells. These transcription regulators are responsible for many important cellular processes …

Functional evolution of bacterial histone-like HU proteins

A Grove - Current issues in molecular biology, 2011 - mdpi.com
Bacterial histone-like HU proteins are critical to maintenance of the nucleoid structure. In
addition, they participate in all DNA-dependent functions, including replication, repair …

The HU and IHF proteins: accessory factors for complex protein-DNA assemblies

ECC Lin, AS Lynch, HA Nash - … of gene expression in Escherichia coli, 1996 - Springer
The apparatus required for the regulation of gene expression varies widely in complexity. At
one extreme, regulation can be achieved by one or two proteins acting at a DNA locus that …

HupB is a bacterial nucleoid-associated protein with an indispensable eukaryotic-like tail

J Hołówka, D Trojanowski, K Ginda, B Wojtaś… - MBio, 2017 - Am Soc Microbiol
In bacteria, chromosomal DNA must be efficiently compacted to fit inside the small cell
compartment while remaining available for the proteins involved in replication, segregation …

Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression

DF Browning, DC Grainger, SJW Busby - Current opinion in microbiology, 2010 - Elsevier
Bacterial nucleoid-associated proteins play a key role in the organisation, replication,
segregation, repair and expression of bacterial chromosomes. Here, we review some recent …

Coordination of genomic structure and transcription by the main bacterial nucleoid‐associated protein HU

M Berger, A Farcas, M Geertz, P Zhelyazkova, K Brix… - EMBO …, 2010 - embopress.org
The histone‐like protein HU is a highly abundant DNA architectural protein that is involved
in compacting the DNA of the bacterial nucleoid and in regulating the main DNA …

Structure of the Nucleoid-Associated Protein Cnu Reveals Common Binding Sites for H-NS in Cnu and Hha,

SH Bae, D Liu, HM Lim, Y Lee, BS Choi - Biochemistry, 2008 - ACS Publications
Cnu is a nucleoid protein that has a high degree of sequence homology with Hha/YmoA
family proteins, which bind to chromatin and regulate the expression of Escherichia coli …