Cationic lipid-and polymer-based nanodevices are considered appropriate alternatives for
virus-based particles for delivery of nucleic acids, including genes and siRNA, into …

Realization of the potential of nucleic acids as drugs is intricately linked to their in vivo
delivery. Cationic lipids demonstrated tremendous potential as safe, efficient and scalable in …

The last few years have witnessed a great advance in the development of nonviral systems
for in vivo targeted delivery of nucleic acids. Lipid nanoparticles (LNPs) are the most …

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming
biological barriers to their delivery. The past two decades have seen the development of …

Non-viral vectors such as cationic lipids are capable of delivering nucleic acids, including
genes, siRNA or antisense RNA into cells, thus potentially resulting in their functional …

RNA interference (RNAi) is a specific gene-silencing mechanism that can be mediated by
the delivery of chemical synthesized small-interfering RNA (siRNA). RNAi might constitute a …

A key hurdle for the further development of RNA interference (RNAi) therapeutics like small
interfering RNA (siRNA) is their safe and effective delivery. Lipids are promising and …

The successful development of nonviral delivery systems for nucleic acids has been
reported extensively over the past number of years. Among them, lipid-based nanoparticles …

Therapeutics based on small interfering RNA (siRNA) have a huge potential for the
treatment of disease but requires sophisticated delivery systems for in vivo applications …

Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …