Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers
In this study, we present results demonstrating that mechanotransduction by vascular
endothelial cadherin (VE-cadherin, also known as CDH5) complexes in endothelial cells …
endothelial cadherin (VE-cadherin, also known as CDH5) complexes in endothelial cells …
Cell–cell junctional mechanotransduction in endothelial remodeling
YL Dorland, S Huveneers - Cellular and Molecular Life Sciences, 2017 - Springer
The vasculature is one of the most dynamic tissues that encounter numerous mechanical
cues derived from pulsatile blood flow, blood pressure, activity of smooth muscle cells in the …
cues derived from pulsatile blood flow, blood pressure, activity of smooth muscle cells in the …
Mechanotransduction at cadherin-mediated adhesions
DE Leckband, Q le Duc, N Wang, J de Rooij - Current opinion in cell …, 2011 - Elsevier
Cell-to-cell junctions are crucial mechanical and signaling hubs that connect cells within
tissues and probe the mechanics of the surrounding environment. Although the capacity of …
tissues and probe the mechanics of the surrounding environment. Although the capacity of …
Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity
The vascular endothelium is subject to diverse mechanical cues that regulate vascular
endothelial barrier function. In addition to rigidity sensing through integrin adhesions …
endothelial barrier function. In addition to rigidity sensing through integrin adhesions …
Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration
DE Conway, MA Schwartz - Cell adhesion & migration, 2015 - Taylor & Francis
Recent work has shown that cadherins at cell-cell junctions bear tensile forces. Using novel
FRET-based tension sensors, we showed first that in response to shear stress, endothelial …
FRET-based tension sensors, we showed first that in response to shear stress, endothelial …
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling
S Huveneers, J Oldenburg, E Spanjaard… - Journal of Cell …, 2012 - rupress.org
To remodel endothelial cell–cell adhesion, inflammatory cytokine-and angiogenic growth
factor–induced signals impinge on the vascular endothelial cadherin (VE-cadherin) …
factor–induced signals impinge on the vascular endothelial cadherin (VE-cadherin) …
E-cadherin-mediated force transduction signals regulate global cell mechanics
This report elucidates an E-cadherin-based force-transduction pathway that triggers
changes in cell mechanics through a mechanism requiring epidermal growth factor receptor …
changes in cell mechanics through a mechanism requiring epidermal growth factor receptor …
Putting VE-cadherin into JAIL for junction remodeling
J Cao, H Schnittler - Journal of Cell Science, 2019 - journals.biologists.com
Junction dynamics of endothelial cells are based on the integration of signal transduction,
cytoskeletal remodeling and contraction, which are necessary for the formation and …
cytoskeletal remodeling and contraction, which are necessary for the formation and …
Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor–dependent signaling
Increased intercellular tension is associated with enhanced cell proliferation and tissue
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …
growth. Here, we present evidence for a force-transduction mechanism that links mechanical …
Neighborly relations: cadherins and mechanotransduction
Cell–cell adhesions are sites where cells experience and resist tugging forces. It has long
been postulated, but not directly tested, that cadherin adhesion molecules may serve in …
been postulated, but not directly tested, that cadherin adhesion molecules may serve in …