The phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin
(mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition …

Abstract The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast
cancer and key pathway aberrations have been identified which drive the different molecular …

Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the
tumor, which in most cases results from its dependence on an oncogene and/or loss of a …

Breast cancer (BC) is the most commonly diagnosed cancer in women. The PI3K/AKT/mTOR
pathway is among the most frequently dysregulated pathways in patients with BC. The …

Breast cancer is one of the most prevalent and devastating malignant diseases in women
worldwide. Fortunately, while breast cancer incidence is still increasing, its death rate is …

Aberrant activation of the PI3K/Akt/mTOR pathway is found in many types of cancer and thus
plays a major role in breast cancer cell proliferation and anti-cancer drug resistance. The …

BACKGROUND: Identification and validation of biomarkers is increasingly important for the
integration of novel targeted agents in the treatment of cancer. The phosphatidylinositol 3 …

Breast cancer (BC) is the most common women cancer and second most common cause of
cancer death in women. A woman living in the United States has 12.3% lifetime risk of being …