Diabetes mellitus is a mounting concern in the United States, as are the mortality and
morbidity that result from its complications. Of particular concern, diabetes patients …

Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma,
sepsis or another serious insult, which increases the risk of opportunistic infections …

Sepsis is a disease caused by infection, which is characterized by a dysregulated immune
response in the host and affects more than 30 million people worldwide each year …

Ulcerative colitis (UC) is a chronic non-specific inflammatory disease that causes
inflammation and ulcers in the intestinal tract. Current therapies focus on the relief of …

BACKGROUND & AIMS: One of the challenges to treating inflammatory bowel disease (IBD)
is to target the site of inflammation. We engineered nanoparticles (NPs) to deliver an anti …

Sepsis is the main cause of death in patients suffering from serious illness. Yet, there is still
no specific treatment for sepsis, and management relies on infection control. Cell membrane …

Synovial fibroblasts in rheumatoid arthritis (RA) joints mediate synovial hyperplasia,
progressive joint destruction, and the potential spread of disease between joints by …

Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be
phenotypically distinct from monocyte-derived macrophages. Whether TRMs and monocyte …

Inflammatory monocyte-derived effector cells play an important role in the pathogenesis of
numerous inflammatory diseases. However, no treatment option exists that is capable of …

Although various local anti-inflammatory therapies for ulcerative colitis have been
developed, rapid drug elimination from inflamed colitis tissue and off-target side effects …