BACKGROUND B7-H3 CAR T-cells effectively eradicate brain tumors in xenograft models
and have proven safe in clinical trials, yet no objective responses were observed in patients …

Background Understanding the intricate dynamics between adoptively transferred immune
cells and the brain tumor immune microenvironment (TIME) is crucial for the development of …

Understanding the intricate dynamics between adoptively transferred immune cells and the
brain tumor immune microenvironment (TIME) is crucial for the development of effective T …

Abstract B7-H3 CAR T-cells have limited efficacy in immunocompetent mouse models
indicating a suppressive role of the tumor immune microenvironment (TIME). In this study …

Understanding interactions between adoptively transferred immune cells and the tumor
immune microenvironment (TIME) is critical for developing successful T-cell based …

We and others have demonstrated that B7-H3 CAR T-cells have potent antitumor responses
in xenograft models for brain tumors; however, these models do not recapitulate the …

Background Glioblastoma (GBM) is the most lethal form of primary brain tumor in adults, with
a 95% five-year mortality rate. Current therapy consists of surgical resection, chemotherapy …

i49 NEURO-ONCOLOGY • June 2023 Page 1 Abstracts i49 NEURO-ONCOLOGY • June 2023
as well as diffusion (ADC) mean values were acquired. Then sRCBV/ADC ratios were …

Background The dismal survival of glioblastoma (GBM) patients urgently calls for the
development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive …

Background The majority of solid tumors in pediatric patients occurs in the central nervous
system, with medulloblastoma accounting for approximately 20% of pediatric brain tumors …