Gene editing on center stage
Smithies et al.(1985) and Jasin and colleagues (1994) provided proof of concept that
homologous recombination (HR) could be applied to the treatment of human disease and …
homologous recombination (HR) could be applied to the treatment of human disease and …
A new class of medicines through DNA editing
MH Porteus - New England Journal of Medicine, 2019 - Mass Medical Soc
Clinical Genome Editing Therapeutic editing of the human genome has long been a holy
grail of genetic medicine. Different approaches are founded on a bedrock of basic laboratory …
grail of genetic medicine. Different approaches are founded on a bedrock of basic laboratory …
After the storm—a responsible path for genome editing
GQ Daley, R Lovell-Badge… - New England Journal of …, 2019 - Mass Medical Soc
A Path Forward for Genome Editing Though the first application of embryo editing was
deeply flawed, not least because it didn't address an unmet clinical need, and has prompted …
deeply flawed, not least because it didn't address an unmet clinical need, and has prompted …
The societal opportunities and challenges of genome editing
D Carroll, RA Charo - Genome biology, 2015 - Springer
The genome editing platforms currently in use have revolutionized the field of genetics. At an
accelerating rate, these tools are entering areas with direct impact on human well being …
accelerating rate, these tools are entering areas with direct impact on human well being …
Advances in genome editing through control of DNA repair pathways
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …
Advancements in genome editing take advantage of these pathways to produce permanent …
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …
living cells—is one of the most recent advances in the field of genome editing. As around …
Towards a new era in medicine: therapeutic genome editing
MH Porteus - Genome biology, 2015 - Springer
Genome editing is the process of precisely modifying the nucleotide sequence of the
genome. It has provided a powerful approach to research questions but, with the …
genome. It has provided a powerful approach to research questions but, with the …
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
H Li, Y Yang, W Hong, M Huang, M Wu… - Signal transduction and …, 2020 - nature.com
Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …
technologies has opened up the possibility of directly targeting and modifying genomic …
Gene therapy comes of age
BACKGROUND Nearly five decades ago, visionary scientists hypothesized that genetic
modification by exogenous DNA might be an effective treatment for inherited human …
modification by exogenous DNA might be an effective treatment for inherited human …
Nuclease‐mediated genome editing: At the front‐line of functional genomics technology
Genome editing with engineered endonucleases is rapidly becoming a staple method in
developmental biology studies. Engineered nucleases permit random or designed genomic …
developmental biology studies. Engineered nucleases permit random or designed genomic …