Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

BF Voight, LJ Scott, V Steinthorsdottir, AP Morris… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

JD Cooper, DJ Smyth, AM Smiles, V Plagnol… - Nature …, 2008 - nature.com
We carried out a meta-analysis of data from three genome-wide association (GWA) studies
of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of …

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

E Zeggini, LJ Scott, R Saxena, BF Voight, JL Marchini… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …

A genomewide scan for loci predisposing to type 2 diabetes in a UK population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides …

S Wiltshire, AT Hattersley, GA Hitman, M Walker… - The American Journal of …, 2001 - cell.com
Improved molecular understanding of the pathogenesis of type 2 diabetes is essential if
current therapeutic and preventative options are to be extended. To identify diabetes …

Genome-wide association studies in type 2 diabetes

MI McCarthy, E Zeggini - Current diabetes reports, 2009 - Springer
Despite numerous candidate gene and linkage studies, the field of type 2 diabetes (T2D)
genetics had until recently succeeded in identifying few genuine disease-susceptibility loci …

Genome-wide association studies and type 2 diabetes

E Wheeler, I Barroso - Briefings in functional genomics, 2011 - academic.oup.com
In recent years, the search for genetic determinants of type 2 diabetes (T2D) has changed
dramatically. Although linkage and small-scale candidate gene studies were highly …

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Meta-Analyses of Glucose and Insulin-related traits … - Nature …, 2012 - nature.com
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes
(T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including …

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

JA Todd, NM Walker, JD Cooper, DJ Smyth… - Nature …, 2007 - nature.com
Abstract The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide
association (GWA) scan on seven diseases, including the multifactorial autoimmune disease …

Type 2 diabetes: genetic data sharing to advance complex disease research

J Flannick, JC Florez - Nature Reviews Genetics, 2016 - nature.com
As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …