PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer
DJ Wozniak, A Kajdacsy-Balla, V Macias… - Nature …, 2017 - nature.com
PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK)
is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation …
is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation …
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
PTEN is frequently mutated in prostate cancer. The tumor suppressor function of PTEN is
attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN …
attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN …
Loss of PTEN accelerates NKX3. 1 degradation to promote prostate cancer progression
NKX3. 1 is the most commonly deleted gene in prostate cancer and a gatekeeper
suppressor. NKX3. 1 is a growth suppressor, mediator of apoptosis, inducer of antioxidants …
suppressor. NKX3. 1 is a growth suppressor, mediator of apoptosis, inducer of antioxidants …
Prostate cancer, PI3K, PTEN and prognosis
HM Wise, MA Hermida, NR Leslie - Clinical science, 2017 - portlandpress.com
Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation
Loss of the tumor suppressor Pten (phosphatase and tensin homolog deleted on
chromosome 10) is thought to mediate the majority of prostate cancers, but the molecular …
chromosome 10) is thought to mediate the majority of prostate cancers, but the molecular …
The role of PTEN in the progression and survival of prostate cancer.
ND Deocampo, H Huang, DJ Tindall - Minerva endocrinologica, 2003 - europepmc.org
PTEN (phosphatase and tensin homologue deleted on chromosome-10), a dual specificity
phosphatase, is a tumor suppressor gene whose inactivation has been associated with …
phosphatase, is a tumor suppressor gene whose inactivation has been associated with …
The PTEN conundrum: how to target PTEN-deficient prostate cancer
DJ Turnham, N Bullock, MS Dass, JN Staffurth… - Cells, 2020 - mdpi.com
Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
[HTML][HTML] Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression
Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we
identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We …
identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We …
Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells
DJ Mulholland, N Kobayashi, M Ruscetti, A Zhi… - Cancer research, 2012 - AACR
Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …
PTEN-deficient tumors depend on AKT2 for maintenance and survival
Loss of PTEN is a common event in many cancers and leads to hyperactivation of the PI3K–
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …