Aims Collagen, as a component of the extracellular matrix, has been linked to
atherosclerotic plaque formation and stability. Activation of LOX-1, a lectin-like oxidized low …

Atherosclerosis is associated with oxidative stress and inflammation, and upregulation of
LOX-1, an endothelial receptor for oxidized LDL (oxLDL). Here, we describe generation of …

Aims Lectin-like oxLDL receptor-1 (LOX-1) mediates the uptake of oxidized low-density
lipoprotein (oxLDL) in endothelial cells and macrophages. However, the different …

Background Atherosclerosis is associated with macrophage accumulation. LOX-1 has been
shown to induce macrophage attachment, and its deletion (LOX-1 knockout, KO) reduces …

Background—Oxidized LDL (ox-LDL) accumulation in the atherosclerotic region may
enhance plaque instability. Both accumulation of ox-LDL and expression of its lectin-like …

Lectin-like oxidized LDL receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL (Ox-
LDL), has been implicated in vascular cell dysfunction related to atherosclerotic plaque …

Objectives Hypertension is a powerful independent risk factor for atherosclerotic
cardiovascular diseases; however, the precise molecular mechanisms whereby …

Endothelial dysfunction induced by oxidized low-density lipoprotein (OxLDL) has been
implicated in the pathogenesis of atherosclerosis and vasculopathy. Increased expression of …

Background: Despite increasing in vitro evidence that lectin-like oxidized low density
lipoprotein (LDL) receptor-1 (LOX-1), a cell-surface receptor for oxidized LDL, is implicated …

AIMS: The oxidized low-density lipoprotein receptor LOX-1 is up-regulated on activated
endothelial cells, for example, the endothelium of atherosclerosis-prone sites, in both human …