The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives
of children with bone or soft tissue sarcomas is described. It is proposed that germ cell …

Family history of cancer and features of the Li-Fraumeni syndrome (LFS) were investigated
in 42 patients with soft tissue sarcoma or osteosarcoma in a pediatric hospital in Mexico City …

In 1969 Li and Fraumeni identified, from a systematic study of 648 children with
rhabdomyosarcomas, five families in which a sibling or a cousin was affected by sarcoma (Li …

Several familial cancer syndromes have been identified. The syndrome of sarcomas, breast
cancer and other neoplasms, known as Li‐Fraumeni syndrome, is characterized by several …

Genetic susceptibility to cancer has been the focus of much recent research. A number of
clearly defined, inherited conditions are known to predispose to specific cancers, for …

The first two families to be identified in the United Kingdom with the Li-Fraumeni syndrome
of familial cancer are reported. The first family comprises breast carcinoma in the mother and …

IN 1969, FP Li and JF Fraumeni described four families in which childhood soft tissue
sarcoma was associated with early onset breast cancer and other early onset cancers in …

Scrutiny of the family pedigrees of a population-based series of 176 children diagnosed with
Wilms' tumor between 1954 and 1990, along with a review of the literature on the Li …

Abstract The Li-Fraumeni cancer family syndrome is manifested by susceptibility to breast
cancer, sarcomas, and other neoplasms in children and young adults. The present study …

The goal of this review is to demonstrate the effective interaction of epidemiologic methods
and molecular genetics in the identification of familial cancer predisposition. The example …