Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical
complex and can trigger migraine. PACAP levels were measured using a sensitive …

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are widely
distributed at different levels of the pain-processing pathway. Its action at the peripheral …

The origin of migraine pain has not yet been clarified, but accumulating data point to
neuropeptides present in the perivascular space of cranial vessels as important mediators of …

Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a
wide range of functions, such as nociception and in primary headaches. Regarding its …

Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …

Background Several neurotransmitters are expressed in the neurons of the trigeminal
ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide …

Background In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–
38) is a potent migraine provoking substance and the accompanying long lasting flushing …

Migraine is a complex disorder with a wide spectrum of clinical symptoms, and affects more
than 16% of the general population. Despite its high heritability, the genetic basis of …

The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary
adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large …

Background Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed
in the nervous system and is involved in migraine pathophysiology. Understanding the …