Leptin seems to play an important role in the generation and maintenance of immune
responses. Leptin is a cytokine similar in structure to interleukin 2, an important T-cell growth …

White adipose tissue is currently considered to be an active endocrine organ that secretes a
plethora of factors named adipokines, most of them proinflammatory in nature, which …

Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular
disease, which together account for most obesity‐related morbidity and mortality. Decreased …

Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue
mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

The discovery of the archetypal adipocytokine leptin and how it regulates energy
homeostasis have represented breakthroughs in our understanding of the endocrine …

Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However,
the leptin receptor is expressed not only in the central nervous system, but also in other …

Leptin is capable of modulating the immune response. Proinflammatory cytokines induce
leptin production, and we now demonstrate that leptin can directly activate the inflammatory …

There is increasing evidence that leptin affects immune responses and that in the absence
of leptin, immunity is suboptimal. Most data so far indicate that leptin increases …

Leptin is an adipocyte-secreted hormone that centrally regulates weight control. However,
leptin receptor is expressed not only in the central nervous system, but also in other systems …