Drug addiction has often been described as a “hijacking” of the brain circuits involved in
learning and memory. Glutamate is the principal excitatory neurotransmitter in the brain, and …

A growing body of evidence suggests that changes in glutamate transporter expression may
be a factor that is common to many neuropsychiatric disorders. As an example, reduced …

Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …

Well-developed cellular mechanisms exist to preserve glutamate homeostasis and regulate
extrasynaptic glutamate levels. Accumulating evidence indicates that disruptions in …

Emerging evidence indicates that many aspects of alcohol and drug dependence involve
changes in glutamate transmission. A number of studies have reported that drugs of abuse …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Historically, brain catecholamine systems have been the primary focus of studies examining
the neural substrates of drug addiction. In the past two decades, however, a wealth of …

Our laboratory and others have previously shown that glutamate transmission is required for
chronic amphetamine-induced neuroadaptations, and that glutamate transmission itself is …