Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

The hypoxic condition is a common feature that negatively impacts the efficacy of radio-and
chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate …

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

We have previously shown that radiation increases HIF-1 activity in tumors, causing
significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on …

Abstract Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to
hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF …