The TRPM ion channel subfamily: molecular, biophysical and functional features

A Fleig, R Penner - Trends in pharmacological sciences, 2004 - cell.com
Significant progress in the molecular and functional characterization of a subfamily of genes
that encode melastatin-related transient receptor potential (TRPM) cation channels has …

TRPM channels in human diseases

I Jimenez, Y Prado, F Marchant, C Otero, F Eltit… - Cells, 2020 - mdpi.com
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …

Molecular and functional characterization of the melastatin-related cation channel TRPM3

C Grimm, R Kraft, S Sauerbruch, G Schultz… - Journal of Biological …, 2003 - ASBMB
Proteins of the mammalian TRP (transient receptor potential) family form a heterogenous
group of cation channels important for cellular Ca 2+ signaling and homeostasis. Here we …

The mammalian melastatin-related transient receptor potential cation channels: an overview

R Kraft, C Harteneck - Pflügers Archiv, 2005 - Springer
The mammalian melastatin-related transient receptor potential (TRPM) subfamily contains
eight members. TRPM proteins, consisting of six putative transmembrane domains and …

Pharmacology of transient receptor potential melastatin channels in the vasculature

A Zholos - British journal of pharmacology, 2010 - Wiley Online Library
Mammalian transient receptor potential melastatin (TRPM) non‐selective cation channels,
the largest TRP subfamily, are widely expressed in excitable and non‐excitable cells where …

Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions

S Lambert, A Drews, O Rizun, TFJ Wagner, A Lis… - Journal of Biological …, 2011 - ASBMB
TRPM1 is the founding member of the melastatin subgroup of transient receptor potential
(TRP) proteins, but it has not yet been firmly established that TRPM1 proteins form ion …

Trpm2

M Faouzi, R Penner - … Transient Receptor Potential (TRP) Cation Channels …, 2014 - Springer
TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM)
family of cation channels. The protein is widely expressed including in the brain, immune …

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2

ZZ Mei, R Xia, DJ Beech, LH Jiang - Journal of Biological Chemistry, 2006 - ASBMB
TRPM2 channels, activated by adenosine diphosphoribose and related molecules, are
assembled as oligomers and most likely tetramers. However, the molecular determinants …

Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels

J Frühwald, JC Londono, S Dembla… - Journal of Biological …, 2012 - ASBMB
TRPM3 channels form ionotropic steroid receptors in the plasma membrane of pancreatic β
and dorsal root ganglion cells and link steroid hormone signaling to insulin release and pain …

The selectivity filter of the cation channel TRPM4

B Nilius, J Prenen, A Janssens, G Owsianik… - Journal of Biological …, 2005 - ASBMB
Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close
homologue, TRPM5, are the only two members of the large transient receptor potential …