Tumour necrosis factor-α (TNFα) was studied in the carrageenin (CG) induced knee-joint
incapacitation, and also in mediating recurrent incapacitation response in knee-joints …

Objective During inflammation in the joint, normal joint movements are usually painful. A
neuronal mechanism for this form of mechanical hyperalgesia is the persistent sensitization …

A new behavioral test is described in which quantitation is independent of the observer and
is sensitive to all classes of analgesics. A computer-assisted device measures the period …

The participation of B1 and B2 types of bradykinin receptors was studied in the rat knee-joint
incapacitation test. Five intra-articular successive hourly administrations of bradykinin …

Objective Pain is the most common symptom of osteoarthritis (OA), yet where it originates in
the joint and how it is driven are unknown. The aim of this study was to identify pain …

It is not known if a cytokine cascade develops during muscle inflammation and whether
cytokines contribute to muscle inflammatory pain. We measured plasma and tissue cytokine …

Endothelin-1, unlike the selective endothelin ETB receptor agonist sarafotoxin S6c, causes
nociception in the rat when injected intra-articularly into the naive knee-joint. By using …

Carrageenan‐induced inflammatory pain lasting hours to days produces a protein kinase C
epsilon (PKCɛ)‐dependent 'primed'state lasting several weeks, during which time injection …

Relevance of tumour necrosis factor-α for the inflammatory and nociceptive responses evoked
by carrageenan in the mouse paw - PMC Back to Top Skip to main content NIH NLM Logo …

Persistent pain associated with inflammatory arthritis is an aggravating factor that decreases
patients' quality of life. Current therapies for joint pain have limited effectiveness and …