Chromosomal rearrangements involving the MLL gene (approved symbol: KMT2A) at 11q23
are associated with different types of hematological malignancies, with more than 70 fusion …

Chromosome 21 and in particular band 21q22, the site of AML1 (RUNX1, CBFA2) gene, is
among the most frequent targets of chromosomal translocations in leukemia observed in …

The t (8; 21)(q22; q22) translocation involving RUNX1 at 21q22 and RUNX1T1 at 8q22 is
observed in 10% of cases of acute myeloid leukemia (AML) M2 subtype. 1 This translocation …

We report a patient with acute myeloid leukemia (AML) and t (3; 21; 8)(q21; q22; q22). This
translocation has not been previously described in de novo or relapsed AML. The patient is …

Background Acute myeloid leukemia (AML) with specific balanced 5q33 translocations are
classified as AML with myelodysplasia-related changes regardless of their morphologic …

Unbalanced translocations, which are created if one of the two derivative chromosomes is
lost, often result in the loss or gain of chromosomal material rather than the formation of …

Aims Chromosome 11q23 translocations, resulting in MLL (KMT2A) rearrangement, have
been well characterised in acute myeloid leukaemia (AML) and acute lymphoblastic …

The classification of acute myeloid leukemia (AML) recognizes a subgroup of diseases with
recurring genetic abnormalities. Translocation (15; 17) is the marker of acute promyelocitic …

Acute myeloid leukemia (AML) with t (8; 21)(q22; q22) is well characterized by its unique
morphology of AML-M2 subtype and favorable prognosis [1]. This recurrent translocation is …

Objective To report two de novo acute myeloid leukemia (AML) patients with t (11; 22)(q23;
q11. 2) and summarize the clinical and biological characteristics. Methods Bone marrow …