The underlying role of oxidative stress in neurodegeneration: a mechanistic review

H Yaribeygi, Y Panahi, B Javadi… - CNS & Neurological …, 2018 - ingentaconnect.com
Background: Neurodegeneration is a condition in which progressive loss of function and
structure of neurons occurs. Several lines of evidence suggest that oxidative stress has a …

Recent updates on the dynamic association between oxidative stress and neurodegenerative disorders.

TA Khan, I Hassan, A Ahmad, A Perveen… - CNS & Neurological …, 2016 - europepmc.org
Free radicals are generated as byproduct of our body metabolism, and their adverse effect
on normal functioning of our body is prevented by body's own antioxidant machinery. Any …

[HTML][HTML] An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases

DM Teleanu, AG Niculescu, II Lungu, CI Radu… - International journal of …, 2022 - mdpi.com
Oxidative stress has been linked with a variety of diseases, being involved in the debut
and/or progress of several neurodegenerative disorders. This review intends to summarize …

[HTML][HTML] Current trends in neurodegeneration: Cross talks between oxidative stress, cell death, and inflammation

T Behl, R Makkar, A Sehgal, S Singh… - International Journal of …, 2021 - mdpi.com
The human body is highly complex and comprises a variety of living cells and extracellular
material, which forms tissues, organs, and organ systems. Human cells tend to turn over …

Mechanism of oxidative stress in neurodegeneration

S Gandhi, AY Abramov - Oxidative medicine and cellular …, 2012 - Wiley Online Library
Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

Oxidative stress and the pathogenesis of neurodegenerative disorders

A Reynolds, C Laurie, RL Mosley… - International review of …, 2007 - Elsevier
Microglia‐derived inflammatory neurotoxins play a principal role in the pathogenesis of
neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …

Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. From molecular mechanisms to therapeutic strategies

A Karpińska, G Gromadzka - Postepy higieny i medycyny …, 2013 - europepmc.org
A lot of evidence exists that oxidative stress is the primary cause of neurodegeneration.
Neurons are more susceptible to oxidative damage than other cells due to their high oxygen …

Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options

B Uttara, AV Singh, P Zamboni… - Current …, 2009 - ingentaconnect.com
Free radicals are common outcome of normal aerobic cellular metabolism. In-built
antioxidant system of body plays its decisive role in prevention of any loss due to free …

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

E Singh, G Devasahayam - Molecular Biology Reports, 2020 - Springer
The intricate physiology of many Central Nervous System (CNS) disorders points towards
oxidative damages of neurons. Various studies have established that oxidative stress is a …

Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease

N Ghosh, R Ghosh, SC Mandal - Free Radical Research, 2011 - Taylor & Francis
Oxidative stress has been consistently linked to ageing-related neurodegenerative
diseases. Neurodegenerative diseases are characterized by progressive dysfunction and …