Dramatic progress has been made in the technologies available to assess global alterations
in mRNA levels in both clinical and research samples. Through commercial services and …

Although the contribution of genetics to complex cardiovascular diseases such as
atherosclerosis has been accepted for quite some time, full and detailed knowledge of the …

Cardiovascular disease is the most important cause of morbidity and mortality in developed
countries, causing twice as many deaths as cancer in the USA. The major cardiovascular …

Cells react to various stimuli by modulating their biological functions through selective
changes in the activities of their constituent proteins. These changes are rendered by …

Microarrays are a high throughput technology that allows the quantification of tens of
thousands of RNA transcripts in a single reaction. This new technology offers the promise of …

Over the last 10 to 20 years, the search for mechanisms responsible for cardiac remodeling
during cardiac hypertrophy and failure has been hampered by the experimental tools …

With the emergence of microarray technology, it is now possible to simultaneously assess
the expression of tens of thousands of gene transcripts, providing a resolution and precision …

The number of cardiovascular publications featuring gene expression profiling technologies
is growing rapidly. This article introduces four profiling techniques; serial analysis of gene …

Microarray technology is a novel tool in molecular biology, capable of quantitating hundreds
or thousands of gene transcripts from a given cell or tissue sample simultaneously. A …

Identifying key genes that regulate the complex diseases of the cardiovascular system can
be greatly facilitated with the use of microarrays. In an effort to obtain a global portrait of …