[HTML][HTML] Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

[HTML][HTML] ACE2: the molecular doorway to SARS-CoV-2

MM Medina-Enríquez, S Lopez-León… - Cell & bioscience, 2020 - Springer
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …

[HTML][HTML] Advances in research on ACE2 as a receptor for 2019-nCoV

J Wu, W Deng, S Li, X Yang - Cellular and Molecular Life Sciences, 2021 - Springer
Currently, a novel coronavirus (SARS-CoV-2, also called 2019-nCoV) has triggered
pandemic Coronavirus Disease 2019 (COVID-19), an acute infectious respiratory disease …

Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review

L Saba, C Gerosa, D Fanni, F Marongiu… - European Review for …, 2020 - iris.unica.it
OBJECTIVE: In human pathology, SARS-CoV-2 utilizes multiple molecular pathways to
determine structural and biochemical changes within the different organs and cell types. The …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
The renin-angiotensin system (RAS) is crucial for the physiology and pathology of all the
organs. Angiotensin-converting enzyme 2 (ACE2) maintains the homeostasis of RAS as a …

[HTML][HTML] SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy

PK Datta, F Liu, T Fischer, J Rappaport, X Qin - Theranostics, 2020 - ncbi.nlm.nih.gov
The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

Association of ACE inhibitors and angiotensin type II blockers with ACE2 overexpression in COVID-19 comorbidities: a pathway-based analytical study

R Parit, S Jayavel - European journal of pharmacology, 2021 - Elsevier
Abstract Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) outbreak is a
major public health concern, which has accounted for> 1.7 million deaths across the world …

[HTML][HTML] Effects of SARS-CoV-2 on cardiovascular system: the dual role of angiotensin-converting enzyme 2 (ACE2) as the virus receptor and homeostasis regulator …

A Aleksova, G Gagno, G Sinagra, AP Beltrami… - International journal of …, 2021 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID …

[HTML][HTML] COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

Interaction of SARS-CoV-2 and other coronavirus with ACE (angiotensin-converting enzyme)-2 as their main receptor: therapeutic implications

AM Davidson, J Wysocki, D Batlle - Hypertension, 2020 - Am Heart Assoc
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 originated from Wuhan,
China, in December 2019 and rapidly spread to other areas worldwide. Since then …