Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by an
increase in amyloid metabolism. The calcium hypothesis of AD explores how activation of …

The possibility that altered calcium (Caz+) regulation plays an important role in neuronal
aging and dementia has been a focus of research interest for about 15 years, and continues …

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

Calcium is a key signaling ion involved in many different intracellular and extracellular
processes ranging from synaptic activity to cell-cell communication and adhesion. The exact …

Calcium is involved in many facets of neuronal physiology, including activity, growth and
differentiation, synaptic plasticity, and learning and memory, as well as pathophysiology …

When properly controlled, Ca2+ fluxes across the plasma membrane and between
intracellular compartments play critical roles in fundamental functions of neurons, including …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

New insights into how Ca 2+ regulates learning and memory have begun to provide clues
as to how the amyloid-dependent remodelling of neuronal Ca 2+ signalling pathways can …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the
basis of emerging evidence since 1994 (The present article, with the subtitle “New evidence …