For over a decade, the European Group for the Study of Resistant Depression (GSRD) has
examined single nucleotide polymorphisms (SNP) and clinical parameters in regard to …

Objectives: Very few studies have investigated clinical features associated with treatment-
resistant depression (TRD) defined as failure of at least 2 consecutive antidepressant trials …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

BackgroundTreatment-resistant depression (TRD) is the most problematic outcome of
depression in terms of functional impairment, suicidal thoughts and decline in physical …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Objective: Up to 15% of depression patients eventually present with treatment-resistant or
refractory depression (TRD), a condition that causes significant social and economic …

Background Clear guidance for successive antidepressant pharmacological treatments for
non-responders in major depression is not well established. Method Based on the …

Major depression does not always remit. Difficult‐to‐treat depression is thought to contribute
to the large disease burden posed by depression. Treatment‐resistant depression (TRD) is …

Background: An increasing amount of attention has been paid to treatment resistant
depression. Although it is quite common to observe nonremission to not just one but …

BACKGROUND: Early identification of depressed individuals at high risk for treatment
resistance could be helpful in selecting optimal setting and intensity of care. At present …