Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts
C Fabbri, SP Hagenaars, C John, AT Williams… - Molecular …, 2021 - nature.com
Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …
by major depressive disorder (MDD). Primary care electronic health records provide an …
Definitions of antidepressant treatment response, remission, nonresponse, partial response, and other relevant outcomes: a focus on treatment-resistant depression
AA Nierenberg, LM DeCecco - Journal of Clinical Psychiatry, 2001 - psychiatrist.com
Multiple definitions have been used to characterize the outcome of treatments for
depression. Beyond the simple criterion of a statistically significant improvement in …
depression. Beyond the simple criterion of a statistically significant improvement in …
Prospective, long-term, multicenter study of the naturalistic outcomes of patients with treatment-resistant depression
DL Dunner, AJ Rush, JM Russell, M Burke… - Journal of Clinical …, 2006 - psychiatrist.com
Background: Treatment-resistant depression (TRD) is a long-term, disabling illness. We
report on the characteristics and outcomes of a large cohort of patients with a level of …
report on the characteristics and outcomes of a large cohort of patients with a level of …
Current trends in the assessment and somatic treatment of resistant/refractory major depression: an overview
A significant proportion of depressed patients eventually present with treatment‐
resistant/refractory major depression (TRD), a debilitating condition that imposes significant …
resistant/refractory major depression (TRD), a debilitating condition that imposes significant …
A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping
Abstract Treatment-resistant depression (TRD) occurs in~ 30% of patients with major
depressive disorder (MDD) but the genetics of TRD was previously poorly investigated …
depressive disorder (MDD) but the genetics of TRD was previously poorly investigated …
A new prediction model for evaluating treatment-resistant depression
Objective: Despite a broad arsenal of antidepressants, about a third of patients suffering
from major depressive disorder (MDD) do not respond sufficiently to adequate treatment …
from major depressive disorder (MDD) do not respond sufficiently to adequate treatment …
What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies
A Fekadu, SC Wooderson, K Markopoulo… - Journal of affective …, 2009 - Elsevier
BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …
for a large proportion of the overall burden caused by depression. We conducted a …
The neglected role of psychotherapy for treatment-resistant depression
JC Markowitz, JH Wright, F Peeters… - American Journal of …, 2022 - Am Psychiatric Assoc
The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …
over 40 years since the recognition that some patients minimally benefit from repeated …
Risk factors for treatment resistance in unipolar depression: a systematic review
D Bennabi, B Aouizerate, W El-Hage, O Doumy… - Journal of affective …, 2015 - Elsevier
Background Treatment resistant depression is a complex disorder and an important source
of morbidity and mortality. Identification of risk factors of resistance may be useful to improve …
of morbidity and mortality. Identification of risk factors of resistance may be useful to improve …
Treatment-resistant depression: prevalence, risk factors, and treatment strategies
ME Thase - The Journal of clinical psychiatry, 2011 - psychiatrist.com
Full symptomatic remission is the optimal outcome for patients with major depression.
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …