Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …

Multiple definitions have been used to characterize the outcome of treatments for
depression. Beyond the simple criterion of a statistically significant improvement in …

Background: Treatment-resistant depression (TRD) is a long-term, disabling illness. We
report on the characteristics and outcomes of a large cohort of patients with a level of …

A significant proportion of depressed patients eventually present with treatment‐
resistant/refractory major depression (TRD), a debilitating condition that imposes significant …

Abstract Treatment-resistant depression (TRD) occurs in~ 30% of patients with major
depressive disorder (MDD) but the genetics of TRD was previously poorly investigated …

Objective: Despite a broad arsenal of antidepressants, about a third of patients suffering
from major depressive disorder (MDD) do not respond sufficiently to adequate treatment …

BACKGROUND: Treatment-resistant depression (TRD) is relatively common and accounts
for a large proportion of the overall burden caused by depression. We conducted a …

The concept of treatment-resistant or treatment-refractory depression (TRD) has evolved
over 40 years since the recognition that some patients minimally benefit from repeated …

Background Treatment resistant depression is a complex disorder and an important source
of morbidity and mortality. Identification of risk factors of resistance may be useful to improve …

Full symptomatic remission is the optimal outcome for patients with major depression.
Unfortunately, initial antidepressant efficacy is limited to partial response for many patients …