Cytotoxic actions and effects on intracellular Ca2+ and cGMP concentrations of sulphur‐containing excitatory amino acids in cultured cerebral cortical neurons

A Frandsen, A Schousboe… - Journal of neuroscience …, 1993 - Wiley Online Library
Abstract Effects of the sulphur‐containing acidic amino acids (SAAs) cysteic acid (CA),
homocysteic acid (HCA), cysteine sulphinic acid (CSA), homocysteine sulphinic acid …

The neurotoxicity of sulfur-containing amino acids in energy-deprived rat hippocampal slices

A Schurr, CA West, MF Heine, BM Rigor - Brain research, 1993 - Elsevier
The rat hippocampal slice preparation and its electrophysiology were used to assess the
toxicity of two sulfur-containing amino acids, l-cysteate (CA) and l-cysteine (CYS). Both …

Neuroactive sulphur amino acids evoke a calcium‐dependent transmitter release from cultured neurones that is sensitive to excitatory amino acid receptor antagonists

J Dunlop, A Grieve, A Schousboe… - Journal of …, 1989 - Wiley Online Library
A dose‐dependent, saturable, and calcium‐dependent release of γ‐[3H] aminobutyrate
([3H] GABA) from cortical neurones and D‐[3H] aspartate from cerebellar granule cells …

Excitatory Amino Acid Induced Cytotoxicity in Cultured Neurons: Role of Intracellular Ca++ Homeostasis

A Schousboe, A Frandsen, P Wahl… - Glutamate, cell death …, 1991 - Springer
In addition to its role as the major excitatory neurotransmitter, L-glutamate may have a toxic
effect on neurons (Olney et al. 1971). This neurotoxic action depends on a multiplicity of …

Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to …

M Zielińska, A Stafiej, RO Law, J Albrecht - Neurotoxicology, 2004 - Elsevier
Treatment of cerebral cortical slices with 5mM ammonium acetate (ammonia) elevated the
glutamine (Gln) content and increased cell volume in the slices, in agreement with the …

Extracellular pH modulates N-methyl-D-aspartate receptor-mediated neurotoxicity and calcium accumulation in rat cortical cultures

T Takadera, Y Shimada, T Mohri - Brain research, 1992 - Elsevier
The effect of extracellular pH (pHo) on the excitotoxicity of N-methyl-d-aspartate (NMDA) in
cultured rat cortical cells was studied. Treatment of cells with 500 μM NMDA for 15 min at …

Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N …

A Gorman, R Griffiths - Neuroscience, 1994 - Elsevier
The stimulatory effect of excitatory sulphur-containing amino acids on inositol phosphate
formation was investigated in primary cultures of cerebellar granule cells. l-Cysteine …

Characterization of the receptor-mediated sulphur amino acid-evoked release of [3H] d-aspartate from primary cultures of cerebellar granule cells

J Dunlop, A Grieve, A Schousboe, R Griffiths - Neurochemistry international, 1990 - Elsevier
A continuous superfusion system was used to study the release of [3 H] d-aspartate from
primary cultures of mouse cerebellar granule cells. A number of neuroactive acidic sulphur …

N-methyl-D-aspartate receptor-mediated increase in intracellular calcium is reduced by ketamine and phencyclidine

CT O'Shaughnessy, D Lodge - European journal of pharmacology, 1988 - Elsevier
Abstract L-Glutamate, N-methyl-D-aspartate, quisqualate and potassium chloride enhanced
Ca 2+ accumulation by rat cortical slices as determined using 45 Ca 2+ uptake and Ca 2+ …

Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur-containing excitatory amino acids

RHP Porter, PJ Roberts - Neuroscience letters, 1993 - Elsevier
The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to
those of l-glutamate and are widely regarded as bona fide transmitter candidates. In this …