Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model
JR Lukens, MW Cruise, MG Lassen… - The Journal of …, 2008 - journals.aai.org
The impaired function of CD8+ T cells is characteristic of hepatitis C virus (HCV) persistent
infection. HCV core protein has been reported to inhibit CD8+ T cell responses. To …
infection. HCV core protein has been reported to inhibit CD8+ T cell responses. To …
Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection
HY Jeong, YJ Lee, SK Seo, SW Lee… - Journal of Leucocyte …, 2008 - academic.oup.com
The establishment of a chronic hepatitis C (CHC) infection is associated with defective HCV-
specific T cell responses. Recent studies suggest that negative T cell regulators such as …
specific T cell responses. Recent studies suggest that negative T cell regulators such as …
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 …
H Radziewicz, CC Ibegbu, ML Fernandez… - Journal of …, 2007 - Am Soc Microbiol
The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-
cell response effective for viral clearance. Evidence from murine chronic viral infections …
cell response effective for viral clearance. Evidence from murine chronic viral infections …
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
N Nakamoto, DE Kaplan, J Coleclough, Y Li, ME Valiga… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation
MW Cruise, HM Melief, J Lukens… - Journal of leukocyte …, 2005 - academic.oup.com
Hepatitis C virus (HCV) infection is associated with a high rate of viral persistence and the
development of chronic liver disease. The expression of HCV core protein in T cells has …
development of chronic liver disease. The expression of HCV core protein in T cells has …
Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV
P Fisicaro, C Valdatta, M Massari, E Loggi, L Ravanetti… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: In patients with chronic hepatitis B virus (HBV) and hepatitis C virus
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
[HTML][HTML] Hepatitis B core antigen upregulates B7-H1 on dendritic cells by activating the AKT/ERK/P38 pathway: a possible mechanism of hepatitis B virus persistence
M Li, ZH Zhou, XH Sun, X Zhang, XJ Zhu, SG Jin… - Laboratory …, 2016 - Elsevier
B7-H1 binding to programmed death-1 may deliver a coinhibitory signal to T cells that is
involved in the regulation of T-cell activation and tolerance. B7-H1 plays a key role in …
involved in the regulation of T-cell activation and tolerance. B7-H1 plays a key role in …
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B
L Chen, Z Zhang, W Chen, Z Zhang, Y Li… - The Journal of …, 2007 - journals.aai.org
Although dysfunctional dendritic cells contribute to inadequate adaptive immunity in chronic
hepatitis B (CHB), underlying molecular mechanisms remain largely undefined. In this study …
hepatitis B (CHB), underlying molecular mechanisms remain largely undefined. In this study …
Cutting edge: programmed death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limited hepatitis B virus infection
Attrition of heterologous virus-specific CD8+ T cells has been demonstrated in murine viral
infection; however, little is known regarding this phenomenon in human viral infections. In …
infection; however, little is known regarding this phenomenon in human viral infections. In …
[PDF][PDF] Antiviral CD8‐mediated responses in chronic HCV carriers with HBV superinfection
C Boni, B Amadei, S Urbani, P Fisicaro, A Zerbini… - …, 2004 - Wiley Online Library
Hepatitis B virus (HBV) superinfection in chronic hepatitis C represents a natural model to
investigate whether or not hepatitis C virus (HCV) can influence priming and maturation of …
investigate whether or not hepatitis C virus (HCV) can influence priming and maturation of …