BACKGROUND/AIMS: Hepatitis C virus leads to chronic hepatitis in the majority of infected
individuals. The mechanism of viral persistence is not completely understood. Hepatitis C …

Attrition of heterologous virus-specific CD8+ T cells has been demonstrated in murine viral
infection; however, little is known regarding this phenomenon in human viral infections. In …

Chronic hepatitis C virus (HCV) infection is a public health issue that often progresses to life-
threatening complications, including liver cirrhosis, fibrosis, and hepatocellular carcinoma …

BACKGROUND & AIMS: The requirement for costimulation of CD8 T-cell priming and
restimulation by nonprofessional antigen-presenting cells is unresolved. Here, we …

Infection with hepatitis C virus (HCV) is associated with persistence in the majority of
individuals. We demonstrate here that the inhibitory molecule programmed death-1 (PD-1) is …

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express
the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling …

Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of
preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection …

Hepatitis C virus (HCV)-specific CD8+ T cells play an important role in the resolution of HCV
infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions …

The functional impairment of HCV‐specific T cell responses is believed to be an important
determinant of HCV persistence, but the functional T cell defects of patients with chronic …

Adaptive T cell responses are critical for controlling HCV infection. While there is clinical
evidence of a relevant role for regulatory T cells in chronic HCV-infected patients, based on …