Hepatitis C virus (HCV) dysregulates innate immune responses and induces persistent viral
infection. We previously demonstrated that HCV core protein impairs IL-12 expression by …

In this study, the effects of wild-type and deletion mutant hepatitis C virus (HCV) core
proteins on the induction of immune responses in BALB/c mice were assessed. p2HA-C145 …

The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a
large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of …

Hepatitis C virus (HCV) has the ability to persist in the majority of infected people. Strong,
multispecific and sustained T-cell response is correlated with viral clearance. The …

Abstract A subset of CD161+ CD56+/− NKT cells can recognize glycolipids presented by
CD1d and positively or negatively regulate inflammatory responses, including those …

Generalized CD8+ T-cell impairment in chronic hepatitis C virus (HCV) infection and the
contribution of liver-infiltrating CD8+ T-cells to the immunopathogenesis of this infection …

A timely, efficient, and coordinated activation of both CD4 and CD8 T cell subsets following
HCV infection is believed to be essential for HCV control. However, to what extent a failure …

ABSTRACT CD8 T cells play a major role in antiviral immune responses. Their importance
for progression to chronic hepatitis C and response to treatment are still unclear. To address …

AIM: To investigate if and how programmed death type-1 (PD-1) expression affects the
natural course of hepatitis B virus (HBV) infection. METHODS: Sixty-four patients in different …

CD4+ T cell responses are impaired in chronic HCV infection. To determine factor (s)
involved in CD4+ T cell dysregulation, we examined the effect of extracellular core on the …