Inhibition of the non-Mevalonate Isoprenoid pathway by reverse Hydroxamate analogues of Fosmidomycin
C Lienau, S Konzuch, T Gräwert, B Illarionov… - Procedia …, 2015 - Elsevier
The non-mevalonate (methylerythritol phosphate, MEP) pathway for isoprenoid biosynthesis
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC
S Konzuch, T Umeda, J Held, S Hähn… - Journal of medicinal …, 2014 - ACS Publications
1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …
New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium
The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)
CT Behrendt, A Kunfermann, V Illarionova… - Journal of medicinal …, 2011 - ACS Publications
Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …
Prodrugs of reverse fosmidomycin analogues
K Brücher, T Gräwert, S Konzuch… - Journal of medicinal …, 2015 - ACS Publications
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key
enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium …
enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium …
Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies
ZK Yao, PM Krai, EF Merino, ME Simpson… - Bioorganic & medicinal …, 2015 - Elsevier
Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …
Mechanism of Action of N-Acyl and N-Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum, a Causative Agent of …
MB Girma, HS Ball, X Wang, RC Brothers… - ACS …, 2021 - ACS Publications
Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …
Targeting an Aromatic Hotspot in Plasmodium falciparum 1‐Deoxy‐d‐xylulose‐5‐phosphate Reductoisomerase with β‐Arylpropyl Analogues of Fosmidomycin
S Sooriyaarachchi, R Chofor, MDP Risseeuw… - …, 2016 - Wiley Online Library
Abstract Blocking the 2‐C‐methyl‐d‐erythrithol‐4‐phosphate pathway for isoprenoid
biosynthesis offers new ways to inhibit the growth of Plasmodium spp. Fosmidomycin [(3‐(N …
biosynthesis offers new ways to inhibit the growth of Plasmodium spp. Fosmidomycin [(3‐(N …
Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate …
MA Abdullaziz, S Takada, B Illarionov… - ACS Infectious …, 2024 - ACS Publications
Reverse analogs of the phosphonohydroxamic acid antibiotic fosmidomycin are potent
inhibitors of the nonmevalonate isoprenoid biosynthesis enzyme 1-deoxy-d-xylulose 5 …
inhibitors of the nonmevalonate isoprenoid biosynthesis enzyme 1-deoxy-d-xylulose 5 …
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity
C Lienau, T Gräwert, LAA Avelar, B Illarionov… - European Journal of …, 2019 - Elsevier
Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …