The non-mevalonate (methylerythritol phosphate, MEP) pathway for isoprenoid biosynthesis
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …

1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …

The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …

Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate
pathway of isoprenoid biosynthesis and a validated antimalarial target, were synthesized …

Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key
enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium …

Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …

Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …

Abstract Blocking the 2‐C‐methyl‐d‐erythrithol‐4‐phosphate pathway for isoprenoid
biosynthesis offers new ways to inhibit the growth of Plasmodium spp. Fosmidomycin [(3‐(N …

Reverse analogs of the phosphonohydroxamic acid antibiotic fosmidomycin are potent
inhibitors of the nonmevalonate isoprenoid biosynthesis enzyme 1-deoxy-d-xylulose 5 …

Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …