Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with …
R Burger, M Guidi, V Calpini, F Lamoth… - Journal of …, 2018 - academic.oup.com
Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …
Population pharmacokinetics/pharmacodynamics and clinical outcomes of meropenem in critically ill patients
A Boonpeng, S Jaruratanasirikul… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model
IK Minichmayr, JA Roberts, OR Frey… - Journal of …, 2018 - academic.oup.com
Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …
clinical success in ICU patients. Objectives To develop and externally validate a population …
Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a …
F Pea, P Viale, P Cojutti, M Furlanut - Antimicrobial agents and …, 2012 - Am Soc Microbiol
The worrisome increase in Gram-negative bacteria with borderline susceptibility to
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …
Effectiveness of pharmacokinetic/pharmacodynamic-guided meropenem treatment in critically ill patients: a comparative cohort study
A Aldaz, AII Grijalba, A Ortega, I Aquerreta… - Therapeutic drug …, 2021 - journals.lww.com
Background: The proper dosage of antibiotics is a key element in the effective treatment of
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …
infection, especially in critically ill patients. This study aimed to evaluate the efficacy of …
Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis
L Ehmann, M Zoller, IK Minichmayr, C Scharf… - International journal of …, 2019 - Elsevier
Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients: how to achieve best dosage regimen according to the clinical situation
A O'jeanson, R Larcher, C Le Souder, N Djebli… - European journal of …, 2021 - Springer
Abstract Background and Objectives Meropenem is frequently used for the treatment of
severe bacterial infections in critically ill patients. Because critically ill patients are more …
severe bacterial infections in critically ill patients. Because critically ill patients are more …
Impact of maximizing Css/MIC ratio on efficacy of continuous infusion meropenem against documented Gram-negative infections in critically ill patients and population …
Introduction: optimal treatment of Gram-negative infections in critically ill patients is
challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility …
challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility …
Combination of pharmacokinetic and pathogen susceptibility information to optimize meropenem treatment of gram-negative infections in critically Ill patients
U Liebchen, F Weinelt, C Scharf… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Meropenem is one of the most frequently used antibiotics to treat life-threatening infections
in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the …
in critically ill patients. This study aimed to develop a meropenem dosing algorithm for the …
A nonparametric pharmacokinetic approach to determine the optimal dosing regimen for 30-minute and 3-hour meropenem infusions in critically ill patients
Background: Pharmacokinetics of meropenem differ widely in the critically ill population. It is
imperative to maintain meropenem concentrations above the inhibitory concentrations for …
imperative to maintain meropenem concentrations above the inhibitory concentrations for …