Background Optimal anti-bacterial activity of meropenem requires maintenance of its plasma
concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at …

Critically ill patients frequently have substantially altered pharmacokinetics compared to non-
critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial …

Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …

Objective Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial
activity against gram-negative, gram-positive and anaerobic micro-organisms and is …

Background Appropriate antimicrobial dosing is challenging because of changes in
pharmacokinetics (PK) parameters and an increase in multidrug-resistant (MDR) organisms …

Extended infusion (EI) administration of β-lactams can improve target attainment in critically
ill patients with altered pharmacokinetics/pharmacodynamics. To optimize meropenem …

Purposes To gather available meropenem pharmacokinetics and define drug dosing
regimens for Asian critically ill patients receiving CRRT. Methods All necessary …

Background Meropenem is a carbapenem antibiotic commonly used in critically ill patients
to treat severe infections. The available pharmacokinetic (PK) data has been mostly …

Purpose Patients admitted to intensive care unit (ICU) with Klebsiella pneumoniae infections
are characterized by high mortality. The aims of the present study were to investigate the …

INTRODUCTION: De-escalation of antimicrobial therapy is often advocated to reduce the
use of broad-spectrum antibiotics in critically ill patients. However, little data are available on …