The optimal dosing regimen for meropenem in critically ill patients undergoing continuous
renal replacement therapy (CRRT) remains undefined due to small studied sample sizes …

Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …

The aim of this study was to investigate optimal loading doses prior to continuous infusion of
meropenem in critically ill patients. A previously published and successfully evaluated …

This prospective crossover study compared the pharmacokinetics of meropenem by
continuous infusion and by intermittent administration in critically ill patients. Fifteen patients …

The number of pharmacokinetic (PK) models of meropenem is increasing. However, the
daily role of these PK models in the clinic remains unclear, especially for critically ill patients …

Introduction Meropenem bactericidal activity depends on the time when the free drug
concentrations remain above the minimum inhibitory concentration of pathogens. The goal …

In the present study, population pharmacokinetic (PK) analysis was performed based on
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …

Purpose To develop a meropenem population pharmacokinetic model in critically ill patients
with particular focus on optimizing dosing regimens based on renal function. Methods …

Existing evidence is inconclusive whether meropenem dosing should be adjusted in
patients receiving extracorporeal membrane oxygenation (ECMO). Therefore, the aim of this …

Background Severe bacterial infections remain a major challenge in intensive care units
because of their high prevalence and mortality. Adequate antibiotic exposure has been …