One of the first-line drugs for empirical antibiotic therapy in patients with hospital-acquired
infections is meropenem. An often neglected problem in sepsis is that patients with a normal …

OBJECTIVES The objectives of this study were to 1) define extent and potential clinical
impact of increased or decreased renal elimination of meropenem in children with sepsis …

Pharmacokinetic and pharmacodynamic profiles of antibiotics are important in determining
effective dosing regimens. Although minimum inhibitory concentration (MIC) data reflect …

Objective Meropenem is a broad‐spectrum antibiotic used for severe infections. In patients
with chronic end‐stage renal failure, meropenem clearance is reduced and doses must be …

The objectives of this study were to describe meropenem pharmacokinetics (PK) in plasma
and/or subcutaneous adipose tissue (SCT) in critically ill patients receiving extracorporeal …

Meropenem is a carbapenem antibacterial agent that has antimicrobial activity against Gram-
negative, Gram-positive and anaerobic micro-organisms. In vitro studies involving isolates …

Objectives: The aim of this study was to compare the pharmacokinetics and
pharmacodynamics of meropenem when administered by 3 h infusion or bolus injection …

Infections due to meropenem-nonsusceptible bacterial strains (MNBSs) with meropenem
minimum inhibitory concentrations (MICs)≥ 16 mg/L have become an urgent problem …

Purpose. The clinical and economic outcomes of a meropenem dosage strategy based on
pharmacodynamic concepts are retrospectively reviewed. Methods. The medical records of …

Background Meropenem is an anti-Gram-negative antimicrobial, the time-dependent activity
of which may be maximized through administration by continuous infusion. Objectives The …